Frequency of known mutations in early-onset Parkinson disease: implication for genetic counseling: the consortium on risk for early onset Parkinson disease study.

doi:10.1001/archneurol.2010.194

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Article

Frequency of known mutations in early-onset Parkinson disease: implication for genetic counseling: the consortium on risk for early onset Parkinson disease study.

Archives of neurology - 1 Sept 2010

Alcalay Roy N, Caccappolo Elise, Mejia-Santana Helen, Tang Ming Xin, Rosado Llency, Ross Barbara M, Verbitsky Miguel, Kisselev Sergey, Louis Elan D, Comella Cynthia, Colcher Amy, Jennings Danna, Nance Martha A, Bressman Susan B, Scott William K, Tanner Caroline, Mickel Susan, Andrews Howard, Waters Cheryl, Fahn Stanley, Cote Lucien, Frucht Steven, Ford Blair, Rezak Michael, Novak Kevin, Friedman Joseph H, Pfeiffer Ronald, Marsh Laura, Hiner Bradley, Siderowf Andrew, Ottman Ruth, Marder Karen, Clark Lorraine N

Abstract excerpt

OBJECTIVE: To assess the frequency and clinical characteristics of carriers of previously identified mutations in 6 genes associated with early-onset Parkinson disease (PD) and provide empirical data that can be used to inform genetic counseling. DESIGN: Cross-sectional observational study. SETTING: Thirteen movement disorders centers. PATIENTS: Nine hundred fifty-three individuals with early-onset PD defined as...

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Identifiers

PMID: 20837857
DOI: 10.1001/archneurol.2010.194
PMCID: PMC3329730

Genes

PRKN
PINK1
SNCA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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