Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GABAergic Synaptic Inhibition Is Reduced before Seizure Onset in a Genetic Model of Cortical Malformation

18 Oct 2006

Abstract excerpt

Malformations of the neocortex are a common cause of human epilepsy; however, the critical issue of how disturbances in cortical organization render neurons epileptogenic remains controversial. The present study addressed this issue by studying inhibitory structure and function before seizure onset in the telencephalic internal structural heterotopia (tish) rat, which is a genetic model of heightened seizure...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epilepsy research and treatment
Share to Neuroscience and Neuropharmacology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17050714
DOI: 10.1523/jneurosci.2323-06.2006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GABAergic Synaptic Inhibition Is Reduced before Seizure Onset in a Genetic Model of Cortical MalformationPMID 17050714Read ↗

Axon initial segment structural plasticity in animal models of genetic and acquired epilepsy.Semantic proximity Read ↗

Characterization of inhibitory circuits in the malformed hippocampus of Lis1 mutant mice.Semantic proximity Read ↗

A Genetic Animal Model of Human Neocortical Heterotopia Associated with SeizuresSemantic proximity Read ↗

Early suppression of excitability in subcortical band heterotopia modifies epileptogenesis in ratsSemantic proximity Read ↗

Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complexSemantic proximity Read ↗

Layer V Neocortical Neurons From Individuals With Drug-Resistant Epilepsy Show Multiple Synaptic Alterations but Lack Somatic HyperexcitabilitySemantic proximity Read ↗

Cerebral Organoids Uncover Mechanisms of Neural Activity Changes in EpileptogenesisSemantic proximity Read ↗

Synaptic Integration in CA1 Pyramidal Neurons Is Intact despite Deficits in GABAergic Transmission in theScn1aHaploinsufficiency Mouse Model of Dravet SyndromeSemantic proximity Read ↗

Maturation of "neocortex isole" in vivo in mice.Semantic proximity Read ↗

Altered excitatory transmission onto hippocampal interneurons in the IQSEC2 mouse model of X-linked neurodevelopmental disease.Semantic proximity Read ↗

Aberrant sorting of hippocampal complex pyramidal cells in Type I Lissencephaly alters topological innervationSemantic proximity Read ↗

Excitatory but not inhibitory synaptic transmission is reduced in lethargic (Cacnb4(lh)) and tottering (Cacna1atg) mouse thalami.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.