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Article

Axon initial segment structural plasticity in animal models of genetic and acquired epilepsy.

Epilepsy research - 1 Aug 2013

Harty Rosemary C, Kim Tae Hwan, Thomas Evan A, Cardamone Lisa, Jones Nigel C, Petrou Steven, Wimmer Verena C

Abstract excerpt

A novel form of neuronal plasticity, occurring at the axon initial segment (AIS), has recently been described. Lengthening of the AIS and movement away from the soma are consequences of changes in neuronal input and result in alterations in neuronal excitability. We hypothesised that AIS plasticity may play a role in epilepsy, due to chronic changes in neuronal activity. Immunohistochemistry and confocal...

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Identifiers

PMID: 23602553
DOI: 10.1016/j.eplepsyres.2013.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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