Article

Layer V Neocortical Neurons From Individuals With Drug-Resistant Epilepsy Show Multiple Synaptic Alterations but Lack Somatic Hyperexcitability

2025-02-26

Abstract excerpt

Although neuronal hyperexcitability is the primary mechanism underlying seizure activity in epilepsy, little is known about how different neuronal mechanisms at different organizational levels contribute to network hyperexcitability in the human epileptic brain. In this study, we determined a series of cellular and synaptic properties of layer V pyramidal neurons from neocortical tissue of patients with drug-resis...

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Literature Corpus work: 7e6b3592-bf65-5f93-b8f7-066180c0bad9
DOI: 10.1101/2025.02.26.640307

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Layer V Neocortical Neurons From Individuals With Drug-Resistant Epilepsy Show Multiple Synaptic Alterations but Lack Somatic HyperexcitabilityDOI 10.1101/2025.02.26.640307Read

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