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Article

Reduction of malignant phenotype of HEPG2 cell is associated with the expression of connexin 26 but not connexin 32.

Carcinogenesis - 1 Oct 2001

Yano T, Hernandez-Blazquez F J, Omori Y, Yamasaki H

Abstract excerpt

Connexin (Cx) genes have a negative growth effect on tumour cells with certain specificity. However, it is not clear whether each Cx gene can act similarly in growth control. Hepatocytes normally express Cx26 and Cx32 as their major gap junction genes, but HepG2 cells, a hepatoma cell line, are deficient in gap junctional intercellular communication (GJIC) based on the down-regulation of Cx26 and aberrant...

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Source

Identifiers

PMID: 11576997
DOI: 10.1093/carcin/22.10.1593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Reduction of malignant phenotype of HEPG2 cell is associated with the expression of connexin 26 but not connexin 32.PMID 11576997Read ↗

Regulation of cellular invasion and matrix metalloproteinase activity in HepG2 cell by connexin 26 transfection.Semantic proximity Read ↗

Connexin26-mediated gap junctional communication reverses the malignant phenotype of MCF-7 breast cancer cells.Semantic proximity Read ↗

Gap junction proteins connexin32 and connexin43 partially acquire growth-suppressive function in HeLa cells by deletion of their C-terminal tails.Semantic proximity Read ↗

Neoplastic phenotype of gap-junctional intercellular communication-deficient WB rat liver epithelial cells and its reversal by forced expression of connexin 32.Semantic proximity Read ↗

Altered homologous and heterologous gap-junctional intercellular communication in primary human liver tumors associated with aberrant protein localization but not gene mutation of connexin 32.Semantic proximity Read ↗

Connexins Act as Tumor Suppressors in Three-dimensional Mammary Cell Organoids by Regulating Differentiation and AngiogenesisSemantic proximity Read ↗

Cx26 inhibits breast MDA-MB-435 cell tumorigenic properties by a gap junctional intercellular communication-independent mechanism.Semantic proximity Read ↗

Background lesions during a 24-month observation period in connexin 32-deficient mice.Semantic proximity Read ↗

Dominant-negative abrogation of connexin-mediated cell growth control by mutant connexin genes.Semantic proximity Read ↗

Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication.Semantic proximity Read ↗

Delayed liver regeneration and increased susceptibility to chemical hepatocarcinogenesis in transgenic mice expressing a dominant-negative mutant of connexin32 only in the liver.Semantic proximity Read ↗

Cell proliferation and advancement of hepatocarcinogenesis in the rat are associated with a decrease in connexin 32 expression.Semantic proximity Read ↗

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