Article
Dominant-negative abrogation of connexin-mediated cell growth control by mutant connexin genes.
Oncogene - 1 Oct 1997
Duflot-Dancer A, Mesnil M, Yamasaki H
Abstract excerpt
Connexin genes exert negative growth control when transfected into various types of tumor cell lines. We previously demonstrated that connexin 26 (Cx26) suppresses in vitro and in vivo growth of HeLa cells. In this study, we have examined whether certain Cx26 mutants can abrogate cell growth control and the gap junctional intercellular communication (GJIC) capacity of such Cx26-transfected HeLa cells. For this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
