Article
Priming of CD4+ T cells specific for conserved regions of human immunodeficiency virus glycoprotein gp120 in humans immunized with a recombinant envelope protein.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990
Abrignani S, Montagna D, Jeannet M, Wintsch J, Haigwood N L, Shuster J R, Steimer K S, Cruchaud A, Staehelin T
Abstract excerpt
A nonglycosylated denatured form of human immunodeficiency virus (HIV) 1 glycoprotein gp120 (Env 2-3), which does not bind to CD4, was used with muramyl tripeptide as adjuvant to immunize HIV-seronegative healthy volunteers. In all the volunteers, three 50-micrograms injections of Env 2-3 induced priming of CD4+ T cells specific for conserved regions of the native glycosylated gp120. Moreover, we found that...
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