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Article

Human CD4+ cytolytic T lymphocyte responses to a human immunodeficiency virus type 1 gp160 subunit vaccine.

The Journal of infectious diseases - 1 Jul 1993

Stanhope P E, Clements M L, Siliciano R F

Abstract excerpt

The development of an effective vaccine against human immunodeficiency virus type 1 (HIV-1) may require immunization protocols that elicit cytolytic T lymphocytes (CTL) in addition to neutralizing antibodies. This report demonstrates that vaccination of 4 HIV-1-seronegative volunteers with a recombinant HIV-1 gp160 vaccine produced in mammalian cells elicited a CTL response in 3. The observed CTL activity was not...

Topics

AIDS Vaccines
CD4-Positive T-Lymphocytes
Clone Cells
Gene Products, env
HIV Envelope Protein gp160
HIV Infections
HIV-1
Humans
Longitudinal Studies
Phenotype
Protein Precursors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 8099941
DOI: 10.1093/infdis/168.1.92

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8099941-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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