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Article

The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis.

European journal of immunology - 1 Nov 2006

Usui Yoshihiko, Akiba Hisaya, Takeuchi Masaru, Kezuka Takeshi, Takeuchi Aya, Hattori Takaaki, Okunuki Yoko, Yamazaki Tomohide, Yagita Hideo, Usui Masahiko, Okumura Ko

Abstract excerpt

ICOS/B7RP-1 is a new member of the CD28/B7 family of costimulatory molecules and plays differential roles in autoimmune diseases. In this study, we examined the role of ICOS/B7RP-1 pathway in the pathogenesis of mouse experimental autoimmune uveoretinitis (EAU), an animal model of human autoimmune uveitis. ICOS expression was found on infiltrating CD4+ T cells in the region of the retina in EAU-induced mice. The...

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Share to Adoptive Transfer
Share to Antigens, Differentiation, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Inducible T-Cell Co-Stimulator Protein

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Source

Identifiers

PMID: 17039566
DOI: 10.1002/eji.200636138

Genes

ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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