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Article

ICOS-B7 homologous protein interactions are necessary for mercury-induced autoimmunity.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2005

Zheng Yan, Jost Monika, Gaughan John P, Class Reiner, Coyle Anthony J, Monestier Marc

Abstract excerpt

After exposure to subtoxic doses of heavy metals such as mercury, H-2(s) mice develop an autoimmune syndrome consisting of the rapid production of IgG autoantibodies that are highly specific for nucleolar autoantigens and a polyclonal increase in serum IgG1 and IgE. In this study, we explore the role of one of the members of the CD28-B7 costimulation families, ICOS-B7 homologous protein (B7h), in the regulation...

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Share to Antibodies, Antinuclear
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, Differentiation, T-Lymphocyte

Share to B7-1 Antigen

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Share to Inducible T-Cell Co-Stimulator Protein

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Source

Identifiers

PMID: 15728528
DOI: 10.4049/jimmunol.174.5.3117

Genes

ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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