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Article

Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis.

1 Nov 1995

Abstract excerpt

The activation and differentiation of T cells require both antigen/MHC recognition and costimulatory signals. The present studies examined the role of B7-1 (CD80) and B7-2 (CD86) costimulation in the prototypic autoimmune disorder, experimental allergic encephalomyelitis (EAE). In adoptively transferred EAE, in vitro activation of myelin basic protein (MBP)-specific lymph node cells was inhibited by the...

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Identifiers

PMID: 7593605
DOI: 10.1172/jci118274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis.PMID 7593605Read ↗

Kinetics of Expression of Costimulatory Molecules and Their Ligands in Murine Relapsing Experimental Autoimmune Encephalomyelitis In VivoSemantic proximity Read ↗

Studies Using Antigen-Presenting Cells Lacking Expression of Both B7-1 (CD80) and B7-2 (CD86) Show Distinct Requirements for B7 Molecules During Priming Versus Restimulation of Th2 But Not Th1 Cytokine ProductionSemantic proximity Read ↗

Tissue-Specific Up-Regulation of B7-1 Expression and Function During the Course of Murine Relapsing Experimental Autoimmune EncephalomyelitisSemantic proximity Read ↗

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Expression of Costimulatory Molecules CD80 and CD86 in Type 2 Immune-Mediated DiseasesSemantic proximity Read ↗

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Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86.Semantic proximity Read ↗

Yin–Yang of costimulation: crucial controls of immune tolerance and functionSemantic proximity Read ↗

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