Article
Mouse models of experimental autoimmune uveitis.
Ophthalmic research - 1 Jan 2008
Caspi Rachel R, Silver Phyllis B, Luger Dror, Tang Jun, Cortes Lizette M, Pennesi Giuseppina, Mattapallil Mary J, Chan Chi-Chao
Abstract excerpt
The mouse model of experimental autoimmune uveitis, induced by immunization of mice with the retinal protein IRBP, was developed in our laboratory 20 years ago and published in 1988. Since that time it has been adopted by many investigators and has given rise to many studies that helped elucidate genetic influences, dissect the basic mechanisms of pathogenesis and test novel immunotherapeutic paradigms. The...
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