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Article

Differential requirements of naïve and memory T cells for CD28 costimulation in autoimmune pathogenesis.

Histology and histopathology - 1 Oct 1999

Perrin P J, Lovett-Racke A, Phillips S M, Racke M K

Abstract excerpt

Experimental autoimmune encephalomyelitis (EAE) is the most extensively studied animal model of the human disease multiple sclerosis (MS). In EAE, CNS demyelination is induced by immunization with myelin proteins or adoptive transfer of myelin-reactive CD4+ T cells. Since the antigen specificity of the immune response believed to be responsible for the pathology of MS is not well defined, therapies that target...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 10506942
DOI: 10.14670/HH-14.1269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential requirements of naïve and memory T cells for CD28 costimulation in autoimmune pathogenesis.PMID 10506942Read ↗

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