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Article

Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias.

Blood - 15 Feb 2007

Harir Noria, Pecquet Christian, Kerenyi Marc, Sonneck Karoline, Kovacic Boris, Nyga Remy, Brevet Marie, Dhennin Isabelle, Gouilleux-Gruart Valerie, Beug Hartmut, Valent Peter, Lassoued Kaiss, Moriggl Richard, Gouilleux Fabrice

Abstract excerpt

Persistent activation of Stat5 is frequently found in hematologic neoplasms. Studies conducted with constitutively active Stat5 mutants (Stat51*6 and cS5F) have shown that deregulated Stat5 activity promotes leukemogenesis. To investigate the oncogenic properties of these mutants, we used cS5F-ex...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphatidylinositol 3-Kinases

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Identifiers

PMID: 17038539
DOI: 10.1182/blood-2006-01-029918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17038539-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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