Article
Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis.
Cell reports - 20 Nov 2014
Chatterjee Anindya, Ghosh Joydeep, Ramdas Baskar, Mali Raghuveer Singh, Martin Holly, Kobayashi Michihiro, Vemula Sasidhar, Canela Victor H, Waskow Emily R, Visconte Valeria, Tiu Ramon V, Smith Catherine C, Shah Neil, Bunting Kevin D, Boswell H Scott, Liu Yan, Chan Rebecca J, Kapur Reuben
Abstract excerpt
Oncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients with acute myeloid leukemia (AML) and myeloproliferative neoplasms (MPNs), and currently available drugs are largely ineffective. Although Stat5 has been implicated in regulating several myeloid and lymphoid malignancies, how precisely Stat5 regulates leukemogenesis, including its nuclear translocation to induce gene...
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