Article
Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy.
Haematologica - 1 Mar 2014
Bibi Siham, Arslanhan Melis Dilara, Langenfeld Florent, Jeanningros Sylvie, Cerny-Reiterer Sabine, Hadzijusufovic Emir, Tchertanov Luba, Moriggl Richard, Valent Peter, Arock Michel
Abstract excerpt
Chronic myeloid leukemia and systemic mastocytosis are myeloid neoplasms sharing a number of pathogenetic and clinical features. In both conditions, an aberrantly activated oncoprotein with tyrosine kinase activity, namely BCR-ABL1 in chronic myeloid leukemia, and mutant KIT, mostly KIT D816V, in systemic mastocytosis, is key to disease evolution. The appreciation of the role of such tyrosine kinases in these...
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