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Article

Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter.

The Biochemical journal - 15 Aug 2005

Nyga Rémy, Pecquet Christian, Harir Noria, Gu Haihua, Dhennin-Duthille Isabelle, Régnier Aline, Gouilleux-Gruart Valérie, Lassoued Kaïss, Gouilleux Fabrice

Abstract excerpt

The active forms of STAT5A (signal transducer and activator of transcription 5A) and STAT5B are able to relieve the cytokine dependence of haematopoietic cells and to induce leukaemia in mice. We have demonstrated previously that activation of the PI3K (phosphoinositide 3-kinase) signalling cascade plays a major role in cell growth and survival induced by these proteins. Interaction between STAT5 and p85, the...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mitogen-Activated Protein Kinase Kinases

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins c-akt

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Source

Open in PubMed Open full text

Identifiers

PMID: 15833084
DOI: 10.1042/BJ20041523
PMCID: PMC1188271

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter.PMID 15833084Read ↗

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