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Article

Stat5 tetramer formation is associated with leukemogenesis.

Cancer cell - 1 Jan 2005

Moriggl Richard, Sexl Veronika, Kenner Lukas, Duntsch Christopher, Stangl Katharina, Gingras Sebastien, Hoffmeyer Angelika, Bauer Anton, Piekorz Roland, Wang Demin, Bunting Kevin D, Wagner Erwin F, Sonneck Karoline, Valent Peter, Ihle James N, Beug Hartmut

Abstract excerpt

Activation of Stat5 is frequently found in leukemias. To study the mechanism and role of Stat5 activation, we introduced a constitutively activated Stat5a mutant, cS5F, into murine bone marrow (BM) cells. BM transplantation with cS5F-transfected cells caused development of multilineage leukemias in lethally irradiated wild-type or nonirradiated Rag2(-/-) mice. The leukemic cells showed strongly enhanced levels of...

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Identifiers

PMID: 15652752
DOI: 10.1016/j.ccr.2004.12.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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