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Article

Nemo-like kinase (NLK) acts downstream of Notch/Delta signalling to downregulate TCF during mesoderm induction in the sea urchin embryo.

Development (Cambridge, England) - 1 Nov 2006

Röttinger Eric, Croce Jenifer, Lhomond Guy, Besnardeau Lydia, Gache Christian, Lepage Thierry

Abstract excerpt

Studies in Caenorhabditis elegans and vertebrates have established that the MAP kinase-related protein NLK counteracts Wnt signalling by downregulating the transcription factor TCF. Here, we present evidence that during early development of the sea urchin embryo, NLK is expressed in the mesoderma...

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Source

Identifiers

PMID: 17038519
DOI: 10.1242/dev.02603

Genes

NLK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17038519-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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