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Article

The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF.

Nature - 24 Jun 1999

Ishitani T, Ninomiya-Tsuji J, Nagai S, Nishita M, Meneghini M, Barker N, Waterman M, Bowerman B, Clevers H, Shibuya H, Matsumoto K

Abstract excerpt

The Wnt signalling pathway regulates many developmental processes through a complex of beta-catenin and the T-cell factor/lymphoid enhancer factor (TCF/LEF) family of high-mobility-group transcription factors. Wnt stabilizes cytosolic beta-catenin, which then binds to TCF and activates gene transcription. This signalling cascade is conserved in vertebrates, Drosophila and Caenorhabditis elegans. In C. elegans,...

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Source

Identifiers

PMID: 10391247
DOI: 10.1038/21674

Genes

NLK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF.PMID 10391247Read ↗

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Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets.Semantic proximity Read ↗

TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development.Semantic proximity Read ↗

Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin.Semantic proximity Read ↗

Agonistic and antagonistic roles for TNIK and MINK in non-canonical and canonical Wnt signalling.Semantic proximity Read ↗

TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling.Semantic proximity Read ↗

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