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Article

Nifedipine pharmacokinetics are influenced by CYP3A5 genotype when used as a preterm labor tocolytic.

American journal of perinatology - 1 Apr 2013

Haas David M, Quinney Sara K, Clay Jayanti M, Renbarger Jamie L, Hebert Mary F, Clark Shannon, Umans Jason G, Caritis Steve N

Abstract excerpt

OBJECTIVE: To characterize the pharmacokinetics and pharmacogenetics of nifedipine in pregnancy. STUDY DESIGN: Pregnant women receiving oral nifedipine underwent steady-state pharmacokinetic testing over one dosing interval. DNA was obtained and genotyped for cytochrome P450 (CYP) 3A5 and CYP3A4*1B. Nifedipine and oxidized nifedipine concentrations were measured in plasma, and pharmacokinetic parameters were...

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Share to Cytochrome P-450 CYP3A
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nifedipine

Share to Obstetric Labor, Premature

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Source

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Identifiers

PMID: 22875663
DOI: 10.1055/s-0032-1323590
PMCID: PMC4039203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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