DR4 mediates the progression, invasion, metastasis and survival of colorectal cancer through the Sp1/NF1 switch axis on genomic locus.

doi:10.1002/ijc.31318

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

DR4 mediates the progression, invasion, metastasis and survival of colorectal cancer through the Sp1/NF1 switch axis on genomic locus.

International journal of cancer - 15 Jul 2018

Wu Shenshen, Meng Qingtao, Zhang Chengcheng, Sun Hao, Lu Runze, Gao Na, Yang Hongbao, Li Xiaobo, Aschner Michael, Chen Rui

Abstract excerpt

The single nucleotide polymorphism (SNP), -397G > T (rs13278062) polymorphism, in the promoter of Death Receptor 4 (DR4) had been reported to be associated with a significantly increased risk for bladder cancer. However, the association of this SNP with the risk of colorectal cancer has not been reported. In this study, we performed a case-control study in 1,078 colorectal cancer patients and 1,175 matched...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neoplasm Invasiveness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Metastasis

Share to Neoplasm Transplantation

Share to Neurofibromin 1

Share to Receptors, TNF-Related Apoptosis-Inducing Ligand

Share to Sp1 Transcription Factor

Share to Survival Analysis

Share to Up-Regulation

Source

Open in PubMed

Identifiers

PMID: 29446085
DOI: 10.1002/ijc.31318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DR4 mediates the progression, invasion, metastasis and survival of colorectal cancer through the Sp1/NF1 switch axis on genomic locus.PMID 29446085Read ↗

DUSP10 gene polymorphism and risk of colorectal cancer in the Han Chinese population.Semantic proximity Read ↗

Association of four polymorphisms in the death receptor 4 gene with cancer risk: an updated meta-analysis.Semantic proximity Read ↗

Rs10204525 Polymorphism of the Programmed Death (PD-1) Gene Is Associated with Increased Risk in a Saudi Arabian Population with Colorectal Cancer.Semantic proximity Read ↗

FAS rs2234767 and rs1800682 polymorphisms jointly contributed to risk of colorectal cancer by affecting SP1/STAT1 complex recruitment to chromatin.Semantic proximity Read ↗

Rs12516 A allele elevates the risk of colorectal cancer via functional CeRNA network of BDNF-AS, miR-4704-5p and BRCA1.Semantic proximity Read ↗

The joint association of REST and NFKB1 polymorphisms on the risk of colorectal cancer.Semantic proximity Read ↗

[Association of programmed cell death 1 (PDCD1) gene polymorphisms with colorectal cancer among Han Chinese population].Semantic proximity Read ↗

Death receptor 4 variants and colorectal cancer risk.Semantic proximity Read ↗

Polymorphisms in the DUSP10 gene are associated with sex-specific colorectal cancer risk in a Han population.Semantic proximity Read ↗

The protease activated receptor 1 gene variation IVSn -14 A>T is associated with distant metastasis and cancer specific survival in renal cell carcinoma.Semantic proximity Read ↗

PNAS-4 expression and its relationship to p53 in colorectal cancer.Semantic proximity Read ↗

The lncRNA SENCR of polymorphism rs12420823 drives breast cancer progression and its overexpression regulates this process via the miR-3648/FOXD3 axis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.