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Article

Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.

The EMBO journal - 1 Nov 1991

Gould K L, Moreno S, Owen D J, Sazer S, Nurse P

Abstract excerpt

Eukaryotic cell cycle progression requires the periodic activation and inactivation of a protein-serine/threonine kinase which in fission yeast is encoded by the cdc2+ gene. The activity of this gene product, p34cdc2, is controlled by numerous interactions with other proteins and by its phosphorylation state. In fission yeast, p34cdc2 is phosphorylated on two sites, one of which has been identified as Tyr15....

Topics

Amino Acid Sequence
Base Sequence
CDC2 Protein Kinase
DNA, Fungal
Flow Cytometry
Genes, Fungal
Molecular Sequence Data
Mutation
Phosphorylation
Phosphotransferases
Schizosaccharomyces

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Alignment

Threonine

Source

Open in PubMed Open full text

Identifiers

PMID: 1655416
DOI: 10.1002/j.1460-2075.1991.tb04894.x
PMCID: PMC453056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1655416-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.PMID 1655416Read ↗

Regulation of cdc2 activity in Schizosaccharomyces pombe: the role of phosphorylation.Semantic proximity Read ↗

Vertebrate p34cdc2 phosphorylation site mutants: effects upon cell cycle progression in the fission yeast Schizosaccharomyces pombe.Semantic proximity Read ↗

A phosphorylation site mutant of Schizosaccharomyces pombe cdc2p fails to promote the metaphase to anaphase transition.Semantic proximity Read ↗

Regulation of p34cdc2 protein kinase activity by phosphorylation and cyclin binding.Semantic proximity Read ↗

A pre-start checkpoint preventing mitosis in fission yeast acts independently of p34cdc2 tyrosine phosphorylation.Semantic proximity Read ↗

Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase.Semantic proximity Read ↗

Dephosphorylation of threonine 169 of Cdc28 is not required for exit from mitosis but may be necessary for start in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.Semantic proximity Read ↗

Cdc2 tyrosine phosphorylation is not required for the S-phase DNA damage checkpoint in fission yeast.Semantic proximity Read ↗

Interaction of yeast Rvs167 and Pho85 cyclin-dependent kinase complexes may link the cell cycle to the actin cytoskeleton.Semantic proximity Read ↗

T-loop phosphorylation of Arabidopsis CDKA;1 is required for its function and can be partially substituted by an aspartate residue.Semantic proximity Read ↗

Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.Semantic proximity Read ↗

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