Article
Regulation of p34cdc2 protein kinase activity by phosphorylation and cyclin binding.
Ciba Foundation symposium - 1 Jan 1992
Nigg E A, Gallant P, Krek W
Abstract excerpt
Activation of the protein kinase p34cdc2 is required for entry into meiotic or mitotic M phase in all eukaryotic cells. One important mechanism regulating the activity of p34cdc2 during the cell cycle is based on phosphorylation/dephosphorylation. Avian p34cdc2 is phosphorylated on threonine 14 (Thr14), tyrosine 15 (Tyr15), threonine 161 (Thr161) and serine 277 (Ser277). Dephosphorylation of both Thr14 and Tyr15...
Topics
- Amino Acid Sequence
- Animals
- CDC2 Protein Kinase
- Catalysis
- Cyclins
- Humans
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Binding
- Threonine