p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase.

doi:10.1016/0092-8674(95)90215-5

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Article

p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase.

Cell - 15 Dec 1995

Correa-Bordes J, Nurse P

Abstract excerpt

p25rum1 from the fission yeast S. pombe is shown to act as a specific in vitro inhibitor of the p34cdc2/p56cdc13 mitotic kinase. It is also shown that early G1 cells contain p25rum1, which associates with and inhibits the mitotic kinase, and maintains p56cdc13 mitotic B cyclin at a low level, ensuring that these cells do not undergo a premature lethal entry into mitosis. A high level of p25rum1 in G2 cells...

Topics

CDC2 Protein Kinase
Cyclin B
Cyclins
DNA Replication
Enzyme Inhibitors
Fungal Proteins
G1 Phase
Genes, cdc
Mitosis
Mutation
S Phase
Schizosaccharomyces
Schizosaccharomyces pombe Proteins
Temperature

Source

Open in PubMed

Identifiers

PMID: 8521500
DOI: 10.1016/0092-8674(95)90215-5

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