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Article

p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase.

Cell - 15 Dec 1995

Correa-Bordes J, Nurse P

Abstract excerpt

p25rum1 from the fission yeast S. pombe is shown to act as a specific in vitro inhibitor of the p34cdc2/p56cdc13 mitotic kinase. It is also shown that early G1 cells contain p25rum1, which associates with and inhibits the mitotic kinase, and maintains p56cdc13 mitotic B cyclin at a low level, ensuring that these cells do not undergo a premature lethal entry into mitosis. A high level of p25rum1 in G2 cells...

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Identifiers

PMID: 8521500
DOI: 10.1016/0092-8674(95)90215-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase.PMID 8521500Read ↗

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Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2.Semantic proximity Read ↗

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Interaction of cdc2 and rum1 regulates Start and S-phase in fission yeast.Semantic proximity Read ↗

Phosphorylation of CDC25A on SER283 in late S/G2 by CDK/cyclin complexes accelerates mitotic entry.Semantic proximity Read ↗

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Highly Synchronous Mitotic Progression in Schizosaccharomyces pombe Upon Relief of Transient Cdc2-asM17 Inhibition.Semantic proximity Read ↗

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