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Article

Effector-dependent conformational changes in protein kinase C gamma through epitope mapping with inhibitory monoclonal antibodies.

European journal of biochemistry - 27 Dec 1990

Cazaubon S, Webster C, Camoin L, Strosberg A D, Parker P

Abstract excerpt

Three monoclonal antibodies (mAb) directed against the regulatory domain of the protein kinase C gamma (PKC gamma); 15G4, 5A2 and 36G9, were shown to display distinct properties with respect to PKC gamma kinase activity [Cazaubon, S., Marais, R., Parker, P. & Strosberg, A.D. (1989) Eur. J. Biochem. 182, 401-406]. The mAb 5A2 and 36G9, which act as potent inhibitors of the cofactor-dependent kinase activity, can...

Topics

Amino Acid Sequence
Antibodies, Monoclonal
Blotting, Western
Epitopes
Escherichia coli
Genes, Bacterial
Molecular Sequence Data
Mutation
Phorbol 12,13-Dibutyrate
Protein Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Kinase C

Source

Identifiers

PMID: 1702715
DOI: 10.1111/j.1432-1033.1990.tb19472.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1702715-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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