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Article

Protein superfamily evolution and the last universal common ancestor (LUCA).

Journal of molecular evolution - 1 Oct 2006

Ranea Juan A G, Sillero Antonio, Thornton Janet M, Orengo Christine A

Abstract excerpt

By exploiting three-dimensional structure comparison, which is more sensitive than conventional sequence-based methods for detecting remote homology, we have identified a set of 140 ancestral protein domains using very restrictive criteria to minimize the potential error introduced by horizontal gene transfer. These domains are highly likely to have been present in the Last Universal Common Ancestor (LUCA) based...

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PMID: 17021929
DOI: 10.1007/s00239-005-0289-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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