Article
Gene families: the taxonomy of protein paralogs and chimeras.
Science (New York, N.Y.) - 24 Oct 1997
Henikoff S, Greene E A, Pietrokovski S, Bork P, Attwood T K, Hood L
Abstract excerpt
Ancient duplications and rearrangements of protein-coding segments have resulted in complex gene family relationships. Duplications can be tandem or dispersed and can involve entire coding regions or modules that correspond to folded protein domains. As a result, gene products may acquire new specificities, altered recognition properties, or modified functions. Extreme proliferation of some families within an...
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