Article
Gene family evolution and homology: genomics meets phylogenetics.
Annual review of genomics and human genetics - 1 Jan 2000
Thornton J W, DeSalle R
Abstract excerpt
With the advent of high-throughput DNA sequencing and whole-genome analysis, it has become clear that the coding portions of the genome are organized hierarchically in gene families and superfamilies. Because the hierarchy of genes, like that of living organisms, reflects an ancient and continuing process of gene duplication and divergence, many of the conceptual and analytical tools used in phylogenetic...
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