Article
Hepatitis C virus core from two different genotypes has an oncogenic potential but is not sufficient for transforming primary rat embryo fibroblasts in cooperation with the H-ras oncogene.
Journal of virology - 1 Apr 1998
Chang J, Yang S H, Cho Y G, Hwang S B, Hahn Y S, Sung Y C
Abstract excerpt
Persistent infection with hepatitis C virus (HCV) is associated with the development of liver cirrhosis and hepatocellular carcinoma. To examine the oncogenic potential of the HCV core gene product, primary rat embryo fibroblasts (REFs) were transfected with the core gene in the presence or absen...
Topics
- Animals
- Carcinogenicity Tests
- Cell Line
- Cell Transformation, Viral
- Cells, Cultured
- Fibroblasts
- Gene Expression
- Genes, ras
- Genotype
- Hepacivirus
- Humans
- Oncogene Proteins, Viral
- Oncogenes
- Rats
- Rats, Inbred F344