Article
The E6 gene of human papillomavirus type 16 is sufficient for transformation of baby rat kidney cells in cotransfection with activated Ha-ras.
Virology - 1 Jun 1994
Liu Z, Ghai J, Ostrow R S, McGlennen R C, Faras A J
Abstract excerpt
The transforming potential of the E6 open reading frame (ORF) of the human papillomavirus type 16 was investigated with transformation assays in cotransfections with an activated ras gene. The E6 ORF driven by the heterologous CMV promoter could fully transform baby rat kidney cells (BRK) in coop...
Topics
- Animals
- Base Sequence
- Cell Line
- Cell Transformation, Viral
- DNA, Viral
- Gene Expression Regulation, Viral
- Genes, ras
- Kidney
- Molecular Sequence Data
- Oncogene Proteins, Viral
- Open Reading Frames
- Papillomaviridae
- Phenotype
- Promoter Regions, Genetic
- Rats
- Repressor Proteins
- Transfection