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Article

Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants.

Journal of virology - 1 May 1990

Helseth E, Kowalski M, Gabuzda D, Olshevsky U, Haseltine W, Sodroski J

Abstract excerpt

Rapid assays which measure the ability of mutant human immunodeficiency virus type 1 envelope glycoproteins to mediate cell-free and/or cell-to-cell transmission of virus are described. By using these assays, envelope glycoprotein mutants with varying degrees of syncytium-forming ability were tested for ability to complement viral replication in trans. As expected, mutants that dramatically affect association of...

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Identifiers

PMID: 2325207
DOI: 10.1128/JVI.64.5.2416-2420.1990
PMCID: PMC249407

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