Article
Retained in vitro infectivity and cytopathogenicity of HIV-1 despite truncation of the C-terminal tail of the env gene product.
Virology - 1 Jul 1992
Wilk T, Pfeiffer T, Bosch V
Abstract excerpt
Five in-frame stop mutations in the HIV-1 env gene, which lead to the production of env gene products truncated within the cytoplasmic C-terminal tail, have been generated and their effects on membrane fusion capacity, glycoprotein incorporation into virus particles, infectivity, and cytopathogenicity were analyzed. The resulting truncated glycoproteins were processed normally, were transported to the cell...
Topics
- Biological Transport, Active
- DNA Mutational Analysis
- DNA, Viral
- Genes, env
- HIV Envelope Protein gp41
- HIV-1
- Humans
- Mutation
- Protein Processing, Post-Translational
- Viral Fusion Proteins
- Virion