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Article

Effects of deletions in the cytoplasmic domain on biological functions of human immunodeficiency virus type 1 envelope glycoproteins.

Journal of virology - 1 Jun 1992

Gabuzda D H, Lever A, Terwilliger E, Sodroski J

Abstract excerpt

The role of the cytoplasmic domain of the human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins in virus replication was investigated. Deletion of residues 840 to 856 at the carboxyl terminus of gp41 reduced the efficiency of virus entry during an early step in the virus life cycle between CD4 binding and formation of the DNA provirus without affecting envelope glycoprotein synthesis, processing, or...

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Identifiers

PMID: 1583717
DOI: 10.1128/JVI.66.6.3306-3315.1992
PMCID: PMC241108

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