Article
Molecular mapping of the mouse db mutation.
Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 1990
Bahary N, Leibel R L, Joseph L, Friedman J M
Abstract excerpt
Diabetes (db) is an autosomal recessive mutation located in the midportion of mouse chromosome 4 that results in profound obesity with hyperphagia, increased metabolic efficiency, and insulin resistance. To clone this gene and generate a molecular map of the region around this mutation, two genetic crosses were established: an intraspecific backcross between C57BL/6J db/db females and C57BL/6J db/db x DBA/2J +/+...
Topics
- Animals
- Chromosome Mapping
- Crosses, Genetic
- Diabetes Mellitus, Experimental
- Female
- Male
- Mice
- Mice, Inbred Strains
- Mice, Mutant Strains
- Mutation
- Phenotype
- Polymorphism, Restriction Fragment Length