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New insights of epithelial-mesenchymal transition in cancer metastasis

1 Jul 2008

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is a key step during embryonic morphogenesis, heart development, chronic degenerative fibrosis, and cancer metastasis. Several distinct traits have been conveyed by EMT, including cell motility, invasiveness, resistance to apoptosis, and some properties of stem cells. Many signal pathways have contributed to the induction of EMT, such as transforming growth factor-beta,...

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PMID: 18604456
DOI: 10.1111/j.1745-7270.2008.00443.x

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