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Article

Chemical genomics identifies compounds affecting Xenopus laevis pigment cell development.

Molecular bioSystems - 1 Apr 2009

Tomlinson Matthew L, Rejzek Martin, Fidock Mark, Field Robert A, Wheeler Grant N

Abstract excerpt

A forward chemical genomic screen was carried out using Xenopus laevis embryos to identify compounds disrupting pigmented cell development, including the retinal pigment epithelial (RPE) layer of the eye and the melanophores (melanocytes). Phenotypes showing changes in cell migration, morphology and pigmentation were observed. The screen also identified compounds affecting other aspects of Xenopus development...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19396374
DOI: 10.1039/b818695b

Genes

RPE

Provenance

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