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Article

Biphasic pro-melanogenic and pro-apoptotic effects of all-trans-retinoic acid (ATRA) on human melanocytes: time-course study.

Journal of dermatological science - 1 Nov 2013

Baldea Ioana, Costin Gertrude-Emilia, Shellman Yiqun, Kechris Katerina, Olteanu Elena Diana, Filip Adriana, Cosgarea Maria Rodica, Norris David Albert, Birlea Stanca Ariana

Abstract excerpt

BACKGROUND: The effects of retinoids on melanogenesis and their mechanism as depigmenting agents in topical therapy have not been fully elucidated. Conflicting data about their impact on melanogenic pathways have been reported. OBJECTIVE: To investigate the effects of all-trans-retinoic acid (ATRA) on normal human melanocytes from Caucasian subjects. METHODS: We assessed ATRA's cytotoxicity by measuring viability...

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PMID: 23867358
DOI: 10.1016/j.jdermsci.2013.06.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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