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Article

129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation.

The Journal of experimental medicine - 18 Aug 2003

McDonald John P, Frank Ekaterina G, Plosky Brian S, Rogozin Igor B, Masutani Chikahide, Hanaoka Fumio, Woodgate Roger, Gearhart Patricia J

Abstract excerpt

Recent studies suggest that DNA polymerase eta (poleta) and DNA polymerase iota (poliota) are involved in somatic hypermutation of immunoglobulin variable genes. To test the role of poliota in generating mutations in an animal model, we first characterized the biochemical properties of murine poliota. Like its human counterpart, murine poliota is extremely error-prone when catalyzing synthesis on a variety of DNA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12925679
DOI: 10.1084/jem.20030767
PMCID: PMC2194173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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