Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1.

Human molecular genetics - 15 Oct 2008

Stiff Tom, Cerosaletti Karen, Concannon Patrick, O'Driscoll Mark, Jeggo Penny A

Abstract excerpt

Ataxia telangiectasia and Rad3-related (ATR) is a phosphoinositol-3-kinase like kinase (PIKK) that initiates a signal transduction response to replication fork stalling. Defects in ATR signalling have been reported in several disorders characterized by microcephaly and growth delay. Here, we gain insight into factors influencing the ATR signalling pathway and consider how they can be exploited for diagnostic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia
Share to Ataxia Telangiectasia Mutated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to G2 Phase

Share to Histones

Share to Intracellular Signaling Peptides and Proteins

Share to Tumor Suppressor p53-Binding Protein 1

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 18664457
DOI: 10.1093/hmg/ddn220
PMCID: PMC3708519

Genes

ATR
MDC1
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1.PMID 18664457Read ↗

ATR signalling: more than meeting at the forkSemantic proximity Read ↗

Role of ATM and the Damage Response Mediator Proteins 53BP1 and MDC1 in the Maintenance of G2/M Checkpoint ArrestSemantic proximity Read ↗

The Mre11-Rad50-Nbs1 Complex Acts Both Upstream and Downstream of Ataxia Telangiectasia Mutated and Rad3-related Protein (ATR) to Regulate the S-phase Checkpoint following UV TreatmentSemantic proximity Read ↗

Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation.Semantic proximity Read ↗

Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replicationSemantic proximity Read ↗

ATR signaling at a glanceSemantic proximity Read ↗

G2 damage checkpoints: what is the turn-on?Semantic proximity Read ↗

Rad9/53BP1 promotes crossover recombination DNA repair by limiting the Sgs1 and Mph1 helicasesSemantic proximity Read ↗

Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathwaySemantic proximity Read ↗

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrestSemantic proximity Read ↗

Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in polynucleotide kinase/phosphatase mutant of fission yeastSemantic proximity Read ↗

ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.