Article
[Molecular targets and novel pharmacological options to prevent myocardial hypertrophic remodeling].
Giornale italiano di cardiologia (2006) - 1 Mar 2016
Coppini Raffaele, Ferrantini Cecilia, Poggesi Corrado, Mugelli Alessandro, Olivotto Iacopo
Abstract excerpt
Myocardial hypertrophic remodeling is a pathophysiological feature of several cardiac conditions and is the hallmark of hypertrophic cardiomyopathy (HCM), the most common monogenic inherited disease of the heart. In recent years, preclinical and clinical studies investigated the underlying molecular mechanisms and intracellular signaling pathways involved in pathologic cardiomyocyte hypertrophy and highlighted a...
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