Article
Deficiency of cell cycle checkpoints and DNA repair system predispose individuals to esophageal cancer.
Mutation research - 1 Dec 2006
Shao Lina, Hittelman Walter N, Lin Jie, Yang Hushan, Ajani Jaffer A, Wu Xifeng
Abstract excerpt
Cell cycle checkpoints and DNA repair capacity are critical for the maintenance of genome integrity. We hypothesized that, in comparison to healthy controls, esophageal cancer patients might have a higher frequency of deficiencies in cell cycle checkpoints and/or DNA repair system. Using flow cytometry and comet assay, we assessed the gamma-radiation-induced S phase and G2-M phase accumulation, and...
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