Article
Pseudo-templated transcription by Escherichia coli RNA polymerase at a mutant promoter.
Genes & development - 1 Oct 1990
Jacques J P, Susskind M M
Abstract excerpt
A G----T mutation at the start-point of transcription of the phage P22 sar promoter (sar + 1T) causes a novel defect in promoter clearance by Escherichia coli RNA polymerase (RNAP) in vitro. Under standard transcription conditions, in the presence of high concentrations of all four NTPs, the predominant products from this promoter are poly(U) chains of varying length. Because the mutation creates a run of four T:...
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