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Article

Mechanistic insights on the folding of a large ribozyme during transcription.

Biochemistry - 24 May 2005

Wong Terrence, Sosnick Tobin R, Pan Tao

Abstract excerpt

RNA folding during transcription resembles folding in a cellular environment. We previously investigated the folding of a large ribozyme derived from a bacterial RNase P RNA during its transcription by the Escherichia coli RNA polymerase and the effect of the elongation factor NusA. We found that transcriptional pausing at a specific site induced by NusA significantly altered the folding pathway. In this work, we...

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PMID: 15895996
DOI: 10.1021/bi047560l

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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