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Article

Parathyroid Hormone Induces Bone Cell Motility and Loss of Mature Osteocyte Phenotype through L-Calcium Channel Dependent and Independent Mechanisms.

PloS one - 1 Jan 2015

Prideaux Matthew, Dallas Sarah L, Zhao Ning, Johnsrud Erica D, Veno Patricia A, Guo Dayong, Mishina Yuji, Harris Stephen E, Bonewald Lynda F

Abstract excerpt

Parathyroid Hormone (PTH) can exert both anabolic and catabolic effects on the skeleton, potentially through expression of the PTH type1 receptor (PTH1R), which is highly expressed in osteocytes. To determine the cellular and molecular mechanisms responsible, we examined the effects of PTH on osteoblast to osteocyte differentiation using primary osteocytes and the IDG-SW3 murine cell line, which differentiate...

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Identifiers

PMID: 25942444
DOI: 10.1371/journal.pone.0125731
PMCID: PMC4420268

Genes

PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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