Article
Human osteoclast and giant cell differentiation: the apparent switch from nonspecific esterase to tartrate resistant acid phosphatase activity coincides with the in situ expression of osteopontin mRNA.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society - 1 Dec 1995
Connor J R, Dodds R A, James I E, Gowen M
Abstract excerpt
Animal model and in vitro cultures suggest that osteoclasts and cells of the mononuclear phagocyte system share a common precursor. However, the human osteoclast precursor has not been positively identified. We attempted to identify the precursor in situ by using a number of osteoclast- and macro...
Topics
- Acid Phosphatase
- Bone and Bones
- Cell Differentiation
- Connective Tissue
- Esterases
- Giant Cells
- Humans
- Immunohistochemistry
- Isoenzymes
- Osteoarthritis
- Osteoclasts
- Osteopontin
- Phenotype
- RNA, Messenger
- Sialoglycoproteins
- Synovial Membrane
- Tartrate-Resistant Acid Phosphatase