Identification of committed mononuclear precursors for osteoclast-like cells formed in long term human marrow cultures.

doi:10.1210/endo-126-5-2733

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Article

Identification of committed mononuclear precursors for osteoclast-like cells formed in long term human marrow cultures.

Endocrinology - 1 May 1990

Kurihara N, Chenu C, Miller M, Civin C, Roodman G D

Abstract excerpt

Nonadherent marrow mononuclear cells enriched for hematopoietic progenitor cells were cultured in semisolid medium with recombinant human granulocyte-macrophage colony-stimulating factor for 9 days to form colony forming unit-granulocyte macrophage (CFU-GM) colonies. 1,25-Dihydroxyvitamin D was then gently layered over the cultures. After 2 weeks, approximately 30% of the colonies that formed were composed of...

Topics

Antibodies, Monoclonal
Bone Marrow Cells
Bone Resorption
Calcitriol
Cells, Cultured
Colony-Stimulating Factors
Granulocyte-Macrophage Colony-Stimulating Factor
Granulocytes
Growth Substances
Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunoenzyme Techniques

Macrophages

Osteoclasts

Phenotype

Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 2184023
DOI: 10.1210/endo-126-5-2733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2184023-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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