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Article

Evidence of a triosephosphate isomerase non-catalytic function crucial to behavior and longevity.

Journal of cell science - 15 Jul 2013

Roland Bartholomew P, Stuchul Kimberly A, Larsen Samantha B, Amrich Christopher G, Vandemark Andrew P, Celotto Alicia M, Palladino Michael J

Abstract excerpt

Triosephosphate isomerase (TPI) is a glycolytic enzyme that converts dihydroxyacetone phosphate (DHAP) into glyceraldehyde 3-phosphate (GAP). Glycolytic enzyme dysfunction leads to metabolic diseases collectively known as glycolytic enzymopathies. Of these enzymopathies, TPI deficiency is unique in the severity of neurological symptoms. The Drosophila sugarkill mutant closely models TPI deficiency and encodes a...

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Identifiers

PMID: 23641070
DOI: 10.1242/jcs.124586
PMCID: PMC3711204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence of a triosephosphate isomerase non-catalytic function crucial to behavior and longevity.PMID 23641070Read ↗

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