Article
Structural differences among hemagglutinins of influenza A virus subtypes are reflected in their antigenic architecture: analysis of H9 escape mutants.
Journal of virology - 1 Jan 2004
Kaverin Nikolai V, Rudneva Irina A, Ilyushina Natalia A, Lipatov Aleksandr S, Krauss Scott, Webster Robert G
Abstract excerpt
We used a panel of monoclonal antibodies to H9 hemagglutinin to select 18 escape mutants of mouse-adapted influenza A/Swine/Hong Kong/9/98 (H9N2) virus. Cross-reactions of the mutants with the antibodies and the sequencing of hemagglutinin genes revealed two minimally overlapping epitopes. We mapped the amino acid changes to two areas of the recently reported three-dimensional structure of A/Swine/Hong Kong/9/98...
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