Article
Modulation of immunodominant sites in influenza hemagglutinin compromise antigenic variation and select receptor-binding variant viruses.
The Journal of experimental medicine - 1 May 1994
Temoltzin-Palacios F, Thomas D B
Abstract excerpt
The regions of antigenic variation in influenza hemagglutinin (HA) are located on surface-accessible regions in the three-dimensional structure of the HA1 monomer. The aim of this study was to establish whether a novel variant virus, IMUT4, in which we had mutated specific amino acid residues (HA...
Topics
- Animals
- Antibodies, Monoclonal
- Antibodies, Viral
- Antigenic Variation
- Antigens, Viral
- Hemagglutinin Glycoproteins, Influenza Virus
- Hemagglutinins, Viral
- Immunodominant Epitopes
- Mice
- Mice, Inbred CBA
- Mutation